"The aim of our study was to analyse desalivated rat tongue epithelium for histopathological changes, proliferating cell nuclear antigen (Raindance Silver Pendant), and epithelium-associated stromal myofibroblasts [SMF; alpha-smooth muscle actin (alphaSMA)] following 0.001% 4-nitroquinoline 1-oxide (Raindance Necklace) administration in drinking water. Results were compared with those of identically treated but salivated specimens. 4NQO was administered for 7, 14, 22 and 28 weeks," scientists in Tel Aviv, Israel report. "Tongue length was divided into anterior, middle and posterior 'thirds'. Sweetie Bracelet big histopathological changes per 'third' were scored as normal epithelium, hyperplasia, dysplasia, carcinoma-in-situ, and superficial and invasive carcinoma. The PCNA and alphaSMA stains were assessed by a point-counting method. At all time points, the histopathological changes in the anterior and middle thirds were higher in the desalivated than in the salivated group but almost identical in the posterior third (p >0.05). PCNA scores were significantly lower in the desalivated vs. the salivated group at almost all time points Tiffany Charm tongue thirds .
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